The goal of Ghajar and colleauges was to understand the relationship between disseminated tumor cells and the microvasculature. By modulating the endothelial cells, this team was able to profoundly alter the progression of metastatic disease in a breast tumor model.
Nat Cell Biol. 2013 Jul;15(7):807-17. doi: 10.1038/ncb2767. Epub 2013 Jun 2.
Ghajar CM1, Peinado H, Mori H, Matei IR, Evason KJ, Brazier H, Almeida D, Koller A, Hajjar KA, Stainier DY, Chen EI, Lyden D, Bissell MJ.
1Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. cmghajar@lbl.gov