Our values are the critical foundation upon which we have built Angiocrine Bioscience.

Esprit de Corps • Commitment • Excellence • Laser Focus

Our team challenges conventional wisdom and pushes the boundaries of scientific discovery and innovation. Our values are reflected in how we think about the patients we aspire to help, the science we do, how we operate as a company, and who we hire.

We look for energetic, creative, self-motivated people who enjoy the breadth and depth of activities one finds in a small, entrepreneurial company. In joining Angiocrine Bioscience, employees are part of a vibrant multi-disciplinary team, committed to developing innovative engineered cellular therapies for treating numerous medical conditions.

Angiocrine Bioscience is committed to the principles of equal employment opportunity. Applicants are considered for all positions without regard to race, sex, sexual orientation, color, religion, national origin, age and disability or any other status protected by applicable law.

Current Openings
Materials Management Lead, Supply Chain Operations

This position is responsible for receiving, inspecting, disposition, and stocking cGMP and non-GMP supplies for cGMP cell therapy manufacturing at CMOs and internal process development activities.  The individual will be responsible for end-to-end supply planning of engineered cell product for research, pilot, and cGMP production and perform the coordination and monitoring of all cold chain shipments.

Position Role & Responsibilities:

  • Develop, manage, and execute the demand and supply planning process.
  • Oversee materials management operations, including receiving, storage, shipment, inventory management, and order processing of all materials for product development and manufacturing.
  • Manage cell product inventory to ensure on time supply for all pre-clinical and clinical product requirements.
  • Manage demand and supply with 3rd party CMO’s and critical raw material suppliers
  • Collaborate with internal CMC team and external CMO personnel to ensure effective management of raw materials supply to support in-house product development and external manufacturing operations.
  • Work with electronic and paper-based inventory systems to manage/release GMP materials for production at CMOs.
  • Coordinate and perform disposition of all expired materials and maintain applicable documentation.
  • Perform inventory cycle count and physical count.
  • Develop or modify Standard Operating Procedures for material management processes.
  • Ensure that all documentation and materials transactions are completed following Good Documentation Practices.
  • Support preparation of outbound shipments from CMOs.
  • Collaborate with manufacturing, quality control, quality assurance, and product development teams in supporting internal and external materials management operations, and resolution of issues.
  • Assist efforts to resolutions of material non-conformance, deviations, or out of specification reports.
  • Prepare and/or develop reports with key performance indicators to measure supply chain performance.
  • Perform additional job-related duties as required

Some weekend work may be required depending on manufacturing schedules.

Education and Experience:

  • Bachelor’s degree preferable
  • Minimum of 3 years of related experience in a regulated material management environment in biotech or life sciences.
  • Knowledge of inventory management systems.
  • Experience in cell therapy manufacturing is preferred.
  • Must embrace positive, pro-active and “no-excuses” style of execution—must emanate ‘can-do’ attitude.
  • Must be a person who enjoys new challenges in areas where prior guidance is not available.

Additional Desired Skills and Knowledge:

  • Strong computer skills with Word and Excel and other electronic manufacturing systems.
  • Detail oriented team player with effective planning, organization and execution skills.
  • Good organization and time management skills.
  • Ability to work in a high paced team environment.
  • Strong written and verbal skills.

Additional Information:

This position is based in San Diego, CA.

Angiocrine is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now
Cell Therapy Manufacturing Associate

The Cell Therapy Manufacturing Associate is responsible for completing and assisting with daily tasks associated with the production of cells in a manufacturing environment for phase I/II/III distribution at a Contract Manufacturer. The Associate will be responsible for following Batch Production Record (BPR) instructions, Stand Operating Procedures (SOPs), and performing daily tasks in an ISO7 clean room cGMP environment.

Position Role & Responsibilities:

The Cell Therapy Manufacturing Associate will be responsible for the following:

  • Perform production related tasks as assigned by Cell Therapy management at a CMC.
  • Cell thawing, cell passaging, cell feeding, harvesting, cell counting, cryopreservation, sample processing, intermediate formulations, and operation of Bioreactor cell culturing systems.
  • Documentation of each task, understanding verifier versus operator functions, following cleaning procedures, and ensuring aseptic processing techniques.
  • Good Manufacturing Practices (GMP) and clean room safety practices.
  • Assist with the ordering and stocking of supplies/materials to meet changes in production demands.
  • Assist Subject Matter Expert (SME) with providing training for new and existing employees for CMC Cell Therapy team.

Position Requirements:

  • Must have industry hands-on-experience with Adherent cell culture and media supplementation.
  • Aseptic technique, clean room gowning and extensive knowledge of Good Manufacturing Practices (GMPs).
  • Must clothe in clean room gowns to work in a clean room environment.
  • Ability to perform cell counts using Hemocytometer.
  • Ability to perform calculations including cell concentration determination, seeding densities, % viability, weight measurements, and volume.
  • Learn and understand material consumption to assist with the ordering of supplies/materials.
  • Have experience in writing and/or revising Standard Operating Procedures (SOPs), Batch Production Records (BPRs), and other Quality/Compliance related documents.
  • Works collaboratively with internal and external groups across Angiocrine and CMCs.
  • Must work with living human cells and various chemicals.
  • Ability to identify potential equipment or process issues.
  • Must be detail-oriented with an ability to set priorities and organize daily work requirements.
  • Must be able to work as a team member and independently as required.
  • Must be able to lift 50 lbs.  Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Due to the nature of production work, overtime and weekend work is a requirement of employment and is variable based on company needs. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions

Preferred Education and Experience

  • Bachelor’s degree in cell biology or related field with 2 + years industry experience

or

  • Associate’s degree in related area and/or a Biotech Program certificate from an accredited college with 3 + years industry experience.

Position Location:

This position is based in San Diego, CA.

Angiocrine is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now
Manufacturing Supervisor – Cell Therapy

The Manufacturing Supervisor – Cell Therapy, is part of the Angiocrine manufacturing team that supports clinical production of cell therapies at a Contract Manufacturer. The Supervisor is responsible for managing all cell related tasks to produce clinical products. The Supervisor will ensure execution of production plans at the CMC while managing internal manufacturing cell therapy staff performance to meet operational goals.

Position Role & Responsibilities:

  • Manage personnel to execute cell isolation and cell expansion functions at a CMC.
  • Provide leadership, guidance, training and direction to staff in alignment with cGMP requirements.
  • Collaborates with area managers to ensure accuracy and adherence to production schedules.
  • Set daily work activities and roles for staff in collaboration with CMC to meet production demands.
  • Coordinate internal product testing and sample submission to contract laboratories.
  • Assist area manager with Environmental Monitoring monthly projections and changes.
  • Proactively identifies and assesses operational risks, communicates issues to senior management and cross-functional support teams.
  • Assists area manager in the design of a Cell Therapy Cell Expansion training plan and execution.
  • Perform additional job-related duties as required.

Position Requirements:

  • Extensive experience in adherent cell thawing, expansion, feeding, and harvesting; including cell counting, cryopreservation, sample processing, and intermediate formulations.
  • Proficiency in ISO-7 clean room manufacturing and comprehensive knowledge of Good Manufacturing Practices (GMP).
  • Experience with generating large tubing assemblies, autoclaving, identifying and use of tubing connectors (MPC, Luers, etc.).
  • Experience with 50 L to 100 L bioreactor systems including media supplementation, large bore tubing welding, and making aseptic connections from various vessels to a bioreactor.
  • Ability to lead manufacturing teams to adhere to demanding production schedules.
  • Authoring, revising, and reviewing of Batch Records, SOPs, and on the job-training documents.
  • Experienced in troubleshooting, investigation, and root cause analysis in a cGMP environment.
  • Must be able to lift 50 lbs.  Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Must work with living human cells and various chemicals.
  • Due to the nature of production work, overtime and weekend work is a requirement of employment and is variable based on company needs. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Preferred Education and Experience

  • Related Bachelor’s degree (Biology or Biotechnology)
  • 7 + Bio-industry experience with a minimum 5 years cGMP cell culture and/or bioreactors
  • Minimum of 2 years’ experience in a leadership role in a cGMP setting.
  • Professional experience working for a contract manufacturing organization is preferred.

Additional Desired Skills and Knowledge:

  • Strong computer skills with Word and Excel and other electronic manufacturing systems.
  • Detail oriented team player with effective planning, organization and execution skills.
  • Good organization and time management skills.
  • Ability to work in a high paced team environment.
  • Strong written and verbal skills.

Additional Information:

This position is based in San Diego, CA.
Angiocrine is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now
QA Specialist

This position is responsible for maintaining Quality Systems that support the clinical manufacture of cell therapy products. The incumbent will assist in manufacturing batch record and deviations review, internal and contracted product release testing and reporting, and the revision of standard operating procedures and policies through change control. The QA specialist may also support process validations and material management efforts. This is a full-time position and will report to the Directory of Quality.

Position Role & Responsibilities:

  • Support clinical production by ensuring compliance with regulatory and industry guidelines.
  • Manage implementation of required changes with CMO to meet cGMP requirements and internal standards.
  • Develop and manage effective working relationship with CMO personnel
  • Review Manufacturing batch records and deviations
    • Ensure adherence to Good Documentation Practices (GDP)
    • Confirm accuracy in calculations and other reporting
  • Prepare Documentation, Protocols and Standard Operating Procedures (SOPs).
    • Revise Standard Operating Procedures
  • Support Quality Control, Analytical Development, Process Development/Technology Transfer
    • Facilitate internal and contract testing
    • Assist in technology transfer documentation
    • Support Operation and Process Qualifications
  • Perform additional job-related duties as required

Education and Experience:

  • Must be learned in cell biology and be proficient in cell culture in a product development or manufacturing environment.
  • Must embrace positive, pro-active and “no-excuses” style of execution—must emanate ‘can-do’ attitude.
  • Successful candidate must be willing to reside in San Diego County—must be willing to visit CMO site(s).
  • Minimum of 3 years of relevant cGMP experience.
  • Must be a person who enjoys new challenges in areas where prior guidance is not available.
  • Experience in FDA regulations in cell therapy or biopharmaceuticals manufacturing
  • Education: Bachelor’s degree in relevant science discipline is required

Additional Desired Skills and Knowledge:

  • Strong computer skills with Word and Excel and other electronic manufacturing systems.
  • Detail oriented team player with effective planning, organization and execution skills.
  • Good organization and time management skills.
  • Ability to work in a high paced team environment.
  • Strong written and verbal skills.

Additional Information:

This position is based in San Diego, CA.

Angiocrine is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now
Quality Control Associate

The Quality Control Associate will be part of the Angiocrine QC team that supports all QC laboratory activities in support of release testing of a cell-based therapy undergoing clinical investigation. A successful candidate should have some experience in cell/gene-therapy product testing under GMP, including familiarity with aseptic technique, immunoassays, flow cytometry, and PCR. This is a full-time position and will report to the QC Supervisor/Manager.

Position Role & Responsibilities:

  • Working with cells and products of animal or human origin
  • Working with replication-incompetent retrovirus
  • Working with chemicals or potential hazard
  • Knowledge of current good manufacturing practices (cGMP) as they apply to Quality Control
  • Execute daily activities to maintain QC laboratory in a GMP-compliant state, including
  • Keeping current on required training documents
  • Following standard operating procedures (SOPs), protocols, and other instructions from management
  • Ensuring that equipment/instrument maintenance, calibration, and cleaning is properly documented
  • Ensuring segregation of GMP-related materials and test samples
  • Performing release testing for incoming raw materials
  • Maintaining cleanliness and organization of laboratory environment
  • Perform GMP bioanalytical release testing for cell banks and/or finished cell-based drug products
  • Perform GMP stability testing for materials, cell banks, and/or finished drug products
  • Participate in out-of-specification (OOS) investigations and deviations
  • Conduct peer review of data generated in QC lab
  • Maintain inventory of laboratory consumables
  • Assist in the validation of bioanalytical test methods
  • Assist in the qualification of equipment/instruments

Some weekend work may be required depending on testing schedules.
Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Preferred Education and Experience

  • Related Bachelor’s degree (e.g. biology, biotechnology, biochemistry)
  • 1+ years work-related experience in cGMP QC laboratory setting
  • Working familiarity with software such as Microsoft Word, Excel, and PowerPoint
  • Working experience with adherent cells
  • Bioanalytical skills with hands-on knowledge/experience in immunoassay/ELISA, flow cytometry, PCR, and/or other bio-analytical techniques.
  • Effective and clear written and verbal communication
  • Ability to work in a high paced team environment.

Additional Information:

This position is based in San Diego, CA.

Angiocrine is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now
Quality Control Senior Associate

The Quality Control Senior Associate will be part of the Angiocrine QC team that supports all QC laboratory activities in support of release testing of a cell-based therapy undergoing clinical investigation. A successful candidate should have some experience in cell/gene-therapy product testing under GMP, including familiarity with aseptic technique, immunoassays, flow cytometry, and PCR. This is a full-time position and will report to the QC Supervisor/Manager.

Position Responsibilities and Requirements:

  • Working with cells and products of animal or human origin
  • Working with replication-incompetent retrovirus
  • Working with chemicals or potential hazard
  • Knowledge of current good manufacturing practices (cGMP) as they apply to Quality Control
  • Execute daily activities to maintain QC laboratory in a GMP-compliant state, including
    • Keeping current on required training documents
    • Following standard operating procedures (SOPs), protocols, and other instructions from management
    • Ensuring that equipment/instrument maintenance, calibration, and cleaning is properly documented
    • Ensuring segregation of GMP-related materials and test samples
    • Performing release testing for incoming raw materials
    • Maintaining cleanliness and organization of laboratory environment
  • Perform GMP bioanalytical release testing for cell banks and/or finished cell-based drug products
  • Perform GMP stability testing for materials, cell banks, and/or finished drug products
  • Participate in out-of-specification (OOS) investigations and deviations
  • Conduct peer review of data generated in QC lab
  • Maintain inventory of laboratory consumables
  • Assist in the validation of bioanalytical test methods
  • Assist in the qualification of equipment/instruments

Some weekend work may be required depending on testing schedules.
Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Preferred Education and Experience

  • Related Bachelor’s degree (e.g. biology, biotechnology, biochemistry)
  • 3+ years work-related experience in cGMP QC laboratory setting
  • Working familiarity with software such as Microsoft Word, Excel, and PowerPoint
  • Working experience with adherent cells
  • Bioanalytical skills with hands-on knowledge/experience in immunoassay/ELISA, flow cytometry, PCR, and/or other bio-analytical techniques.
  • Effective and clear written and verbal communication
  • Ability to work in a high paced team environment.

Additional Information:

This position is based in San Diego, CA.

Angiocrine is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now
Quality Control Supervisor

The Quality Control Supervisor will be part of the Angiocrine QC team that supports all QC laboratory activities in support of release testing of a cell-based therapy undergoing clinical investigation. A successful candidate should have some experience in cell/gene-therapy product testing under GMP, including familiarity with aseptic technique, immunoassays, flow cytometry, and PCR. This is a full-time position and will report to the Director of Quality.

Position Responsibilities and Requirements:

  • Working with cells and products of animal or human origin
  • Working with replication-incompetent retrovirus
  • Working with chemicals or potential hazard
  • Knowledge of current good manufacturing practices (cGMP) as they apply to Quality Control
  • Supervise daily activities to maintain QC laboratory in a GMP-compliant state, including
    • Keeping current on required training documents
    • Following standard operating procedures (SOPs), protocols, and other instructions from management
    • Ensuring that equipment/instrument maintenance, calibration, and cleaning is properly documented
    • Ensuring segregation of GMP-related materials and test samples
    • Performing release testing for incoming raw materials
    • Maintaining cleanliness and organization of laboratory environment
  • Oversee GMP bioanalytical release testing for cell banks and/or finished cell-based drug products
  • Oversee GMP stability testing for materials, cell banks, and/or finished drug products
  • Conduct out-of-specification (OOS) investigations and deviations
  • Conduct peer review of data generated in QC lab
  • Oversee inventory of laboratory consumables
  • Oversee the validation of bioanalytical test methods
  • Oversee the qualification of equipment/instruments
  • Oversee data trending and other quality metrics
  • Manage QC personnel against performance objectives

Some weekend work may be required depending on testing schedules.
Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Preferred Education and Experience

  • Related Bachelor’s degree (e.g. biology, biotechnology, biochemistry)
  • 5+ years work-related experience in cGMP QC laboratory setting
  • Working familiarity with software such as Microsoft Word, Excel, and PowerPoint
  • Working experience with adherent cells
  • Bioanalytical skills with hands-on knowledge/experience in immunoassay/ELISA, flow cytometry, PCR, and/or other bio-analytical techniques.
  • Effective and clear written and verbal communication
  • Ability to work in a high paced team environment.

Additional Information:

This position is based in San Diego, CA.

Angiocrine is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now