Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells

Here is laid out in detail the alterations to the vasculature of the bone marrow after suffering a myeloablative stress. This work established that prior to any hematopoietic recovery, VEGF must stimulate the sinusoidal endothelial cells to promote a proper recovery.

Cell Stem Cell. 2009 Mar 6;4(3):263-74. doi: 10.1016/j.stem.2009.01.006.

Hooper AT¹, Butler JM, Nolan DJ, Kranz A, Iida K, Kobayashi M, Kopp HG, Shido K, Petit I, Yanger K, James D, Witte L, Zhu Z, Wu Y, Pytowski B, Rosenwaks Z, Mittal V, Sato TN, Rafii S.

¹Howard Hughes Medical Institute, Weill Cornell Medical College, New York, NY 10065, USA.

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