Abstract Developmental pathways that orchestrate the fleeting transition of endothelial cells into hematopoietic stem cells remain undefined. Here we demonstrate a tractable approach for fully […]
Abstract Successful expansion of bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs) would benefit many HSPC transplantation and gene therapy/editing applications. However, current expansion […]
Abstract Endothelial cells that line capillaries are not just passive conduits for delivering blood. Tissue-specific endothelium establishes specialized vascular niches that deploy sets of growth […]
Abstract Pluripotent stem cells (PSCs) represent an alternative hematopoietic stem cell (HSC) source for treating hematopoietic disease. The limited engraftment of human PSC–derived (hPSC-derived) multipotent […]
Abstract Generating engraftable human haematopoietic cells from autologous tissues is a potential route to new therapies for blood diseases. However, directed differentiation of pluripotent stem […]
Abstract The local presence of endothelial cells seems necessary for proper embryonic development of several organs. However, the signals involved are unknown. The glomerulus is […]
This work looked at the process of how the vasculature is stimulated to promote gonad development. Cool found that the interstitial cells express Vegfa, which […]
Angiocrine factors from the vasculature were required to initiate proper hepatic outgrowth and morphogenesis. Science. 2001 Oct 19;294(5542):559-63. Epub 2001 Sep 27. Matsumoto K1, Yoshitomi […]
In this publication, the Melton group is one of the first to discover the role of Angiocrine functions in pancreatic differentiation. Evidence for the importance […]
The goal of Ghajar and colleauges was to understand the relationship between disseminated tumor cells and the microvasculature. By modulating the endothelial cells, this team […]
This review article by one of the pioneers in vascular biology tracks the evolution of our understanding of endothelial cells. J Clin Invest. 2012 Mar […]
Dr. John Chute and colleagues identify pleiotrophin as a regulator of hematopoietic stem cell self-renewal in vivo. The lack of pleiotrophin resulted in impaired hematopoietic […]
This work provides a detailed structure of the vascular niche within the bone marrow. Of the cells found within this vascular niche were the primitive […]
Gakhar and colleagues investigated the ability for prostate cancer (PCa) to bind E-selectin as a mechanism for extravasation and metastasis. VeraVec ECs (E4ORF1 HUVECs) were […]
Dr. Sean Morrison’s laboratory used a generous supply of transgenic drivers of SCF (Stem Cell Factor, Kit Ligand) gene excision, a necessary component of the […]
Dr. Daylon James delves into detail describing the process of generating endothelial cells from human embryonic stem cells. Within the sequence of procedures, the expression […]
Here is laid out in detail the alterations to the vasculature of the bone marrow after suffering a myeloablative stress. This work established that prior […]
The features of the VeraVec technology are based in the modest activation of Akt1 without the need for any oncogenic activity or transformation. Only through […]
After the removal of a single lung, the remaining lung is capable of compensatory growth in an Angiocrine factor dependent manner. Endothelial cells are capable […]
Sinusoidal endothelial cells within the liver are a rich source of Angiocrine factors. Here, endothelial cell derived Wnt2 and HGF are found to be two […]
The vasculature of the bone marrow is indispensable for the recovery of blood lineages after myeloablative stresses. Disruption of the endothelial cells’ ability to produce […]
The amniotic fluid is a source of cellular material which is amenable to reprogramming into endothelial cells. These reprogrammed ECs (rAC-VECs) form a durable platform […]
This is the first demonstration that freshly isolated human umbilical cord blood-derived hematopoietic stem and progenitor cells expand on the VeraVec platform. The expansion gives […]
Gakhar and colleagues investigated the ability for prostate cancer (PCa) to bind E-selectin as a mechanism for extravasation and metastasis. VeraVec ECs (E4ORF1 HUVECs) were […]
Dr. Sean Morrison’s laboratory used a generous supply of transgenic drivers of SCF (Stem Cell Factor, Kit Ligand) gene excision, a necessary component of the […]
The intricacies of the vascular niche in vivo was elucidated in both steady state and regenerating conditions via the transcriptional profiling of various tissues. This […]
This manuscript is the first demonstration of the ability of the VeraVec endothelial cell to survive in culture without serum. Seandel and colleagues demonstrated the […]
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