Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells

Dr. John Chute and colleagues identify pleiotrophin as a regulator of hematopoietic stem cell self-renewal in vivo. The lack of pleiotrophin resulted in impaired hematopoietic recovery following myelosuppression. Finally, the source of pleiotrophin was found to be extrinsic to the hematopoietic cells themselves, and derived from the endothelial cells within the bone marrow.

Nat Med. 2010 Apr;16(4):475-82. doi: 10.1038/nm.2119. Epub 2010 Mar 21.

Himburg HA1, Muramoto GG, Daher P, Meadows SK, Russell JL, Doan P, Chi JT, Salter AB, Lento WE, Reya T, Chao NJ, Chute JP.

1Division of Cellular Therapy, Department of Medicine, Duke University, Durham, North Carolina, USA.

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