Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

Sinusoidal endothelial cells within the liver are a rich source of Angiocrine factors. Here, endothelial cell derived Wnt2 and HGF are found to be two key factors for the regeneration of liver tissue.

Nature. 2010 Nov 11;468(7321):310-5. doi: 10.1038/nature09493.

Ding BS1, Nolan DJ, Butler JM, James D, Babazadeh AO, Rosenwaks Z, Mittal V, Kobayashi H, Shido K, Lyden D, Sato TN, Rabbany SY, Rafii S.

1Howard Hughes Medical Institute, Ansary Stem Cell Institute, and Department of Genetic Medicine, Weill Cornell Medical College, New York, New York 10065, USA.