Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells
The vasculature of the bone marrow is indispensable for the recovery of blood lineages after myeloablative stresses. Disruption of the endothelial cells’ ability to produce [...]
Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFbeta suppression
The amniotic fluid is a source of cellular material which is amenable to reprogramming into endothelial cells. These reprogrammed ECs (rAC-VECs) form a durable platform [...]
Development of a vascular niche platform for expansion of repopulating human cord blood stem and progenitor cells
This is the first demonstration that freshly isolated human umbilical cord blood-derived hematopoietic stem and progenitor cells expand on the VeraVec platform. The expansion gives [...]
Circulating Tumor Cells from Prostate Cancer Patients Interact with E-Selectin under Physiologic Blood Flow
Gakhar and colleagues investigated the ability for prostate cancer (PCa) to bind E-selectin as a mechanism for extravasation and metastasis. VeraVec ECs (E4ORF1 HUVECs) were [...]
Endothelial and perivascular cells maintain haematopoietic stem cells
Dr. Sean Morrison’s laboratory used a generous supply of transgenic drivers of SCF (Stem Cell Factor, Kit Ligand) gene excision, a necessary component of the [...]
Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration
The intricacies of the vascular niche in vivo was elucidated in both steady state and regenerating conditions via the transcriptional profiling of various tissues. This [...]
Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene
This manuscript is the first demonstration of the ability of the VeraVec endothelial cell to survive in culture without serum. Seandel and colleagues demonstrated the [...]