Circulating Tumor Cells from Prostate Cancer Patients Interact with E-Selectin under Physiologic Blood Flow
Gakhar and colleagues investigated the ability for prostate cancer (PCa) to bind E-selectin as a mechanism for extravasation and metastasis. VeraVec ECs (E4ORF1 HUVECs) were [...]
Endothelial and perivascular cells maintain haematopoietic stem cells
Dr. Sean Morrison’s laboratory used a generous supply of transgenic drivers of SCF (Stem Cell Factor, Kit Ligand) gene excision, a necessary component of the [...]
Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration
The intricacies of the vascular niche in vivo was elucidated in both steady state and regenerating conditions via the transcriptional profiling of various tissues. This [...]
Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene
This manuscript is the first demonstration of the ability of the VeraVec endothelial cell to survive in culture without serum. Seandel and colleagues demonstrated the [...]