Induction of pancreatic differentiation by signals from blood vessels
In this publication, the Melton group is one of the first to discover the role of Angiocrine functions in pancreatic differentiation. Evidence for the importance [...]
The perivascular niche regulates breast tumor dormancy
The goal of Ghajar and colleauges was to understand the relationship between disseminated tumor cells and the microvasculature. By modulating the endothelial cells, this team [...]
Endothelium: from cellophane to orchestral maestro
This review article by one of the pioneers in vascular biology tracks the evolution of our understanding of endothelial cells. J Clin Invest. 2012 Mar [...]
Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells
Dr. John Chute and colleagues identify pleiotrophin as a regulator of hematopoietic stem cell self-renewal in vivo. The lack of pleiotrophin resulted in impaired hematopoietic [...]
Identification of a clonally expanding haematopoietic compartment in bone marrow
This work provides a detailed structure of the vascular niche within the bone marrow. Of the cells found within this vascular niche were the primitive [...]
Circulating Tumor Cells from Prostate Cancer Patients Interact with E-Selectin under Physiologic Blood Flow
Gakhar and colleagues investigated the ability for prostate cancer (PCa) to bind E-selectin as a mechanism for extravasation and metastasis. VeraVec ECs (E4ORF1 HUVECs) were [...]
Endothelial and perivascular cells maintain haematopoietic stem cells
Dr. Sean Morrison’s laboratory used a generous supply of transgenic drivers of SCF (Stem Cell Factor, Kit Ligand) gene excision, a necessary component of the [...]
Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent
Dr. Daylon James delves into detail describing the process of generating endothelial cells from human embryonic stem cells. Within the sequence of procedures, the expression [...]
Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells
Here is laid out in detail the alterations to the vasculature of the bone marrow after suffering a myeloablative stress. This work established that prior [...]
Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells
The features of the VeraVec technology are based in the modest activation of Akt1 without the need for any oncogenic activity or transformation. Only through [...]
Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization
After the removal of a single lung, the remaining lung is capable of compensatory growth in an Angiocrine factor dependent manner. Endothelial cells are capable [...]
Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
Sinusoidal endothelial cells within the liver are a rich source of Angiocrine factors. Here, endothelial cell derived Wnt2 and HGF are found to be two [...]