Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells
Dr. John Chute and colleagues identify pleiotrophin as a regulator of hematopoietic stem cell self-renewal in vivo. The lack of pleiotrophin resulted in impaired hematopoietic [...]
Identification of a clonally expanding haematopoietic compartment in bone marrow
This work provides a detailed structure of the vascular niche within the bone marrow. Of the cells found within this vascular niche were the primitive [...]
Circulating Tumor Cells from Prostate Cancer Patients Interact with E-Selectin under Physiologic Blood Flow
Gakhar and colleagues investigated the ability for prostate cancer (PCa) to bind E-selectin as a mechanism for extravasation and metastasis. VeraVec ECs (E4ORF1 HUVECs) were [...]
Endothelial and perivascular cells maintain haematopoietic stem cells
Dr. Sean Morrison’s laboratory used a generous supply of transgenic drivers of SCF (Stem Cell Factor, Kit Ligand) gene excision, a necessary component of the [...]
Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent
Dr. Daylon James delves into detail describing the process of generating endothelial cells from human embryonic stem cells. Within the sequence of procedures, the expression [...]
Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells
Here is laid out in detail the alterations to the vasculature of the bone marrow after suffering a myeloablative stress. This work established that prior [...]
Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells
The features of the VeraVec technology are based in the modest activation of Akt1 without the need for any oncogenic activity or transformation. Only through [...]
Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization
After the removal of a single lung, the remaining lung is capable of compensatory growth in an Angiocrine factor dependent manner. Endothelial cells are capable [...]
Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
Sinusoidal endothelial cells within the liver are a rich source of Angiocrine factors. Here, endothelial cell derived Wnt2 and HGF are found to be two [...]
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells
The vasculature of the bone marrow is indispensable for the recovery of blood lineages after myeloablative stresses. Disruption of the endothelial cells’ ability to produce [...]
Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFbeta suppression
The amniotic fluid is a source of cellular material which is amenable to reprogramming into endothelial cells. These reprogrammed ECs (rAC-VECs) form a durable platform [...]
Development of a vascular niche platform for expansion of repopulating human cord blood stem and progenitor cells
This is the first demonstration that freshly isolated human umbilical cord blood-derived hematopoietic stem and progenitor cells expand on the VeraVec platform. The expansion gives [...]