Open Label Dose Escalation Trial of AB-205 (E-CEL® cells) in Adults with Lymphoma Undergoing High-Dose Therapy and Autologous Hematopoietic Cell Transplantation (HDT-AHCT)
March 16, 2021 Abstract: HDT-AHCT is a standard curative therapy for patients with relapsed, high risk lymphomas. Severe regimen-related toxicities (SRRT) occur frequently after [...]
Results of an Open Label Dose Escalation Trial of AB-205 (E-CEL® cells) in Adults with Lymphoma Undergoing High-Dose Therapy and Autologous Hematopoietic Cell Transplantation (HDT-AHCT)
Abstract: HDT-AHCT is a standard potentially curative therapy for aggressive lymphomas. Despite improvements in supportive care, severe regimen-related toxicities (SRRT) are common and may [...]
Results of a Phase 1 Open Label Dose Escalation Trial of AB-205 (Allogeneic Engineered Endothelial Cell Therapy) in Adults with Lymphoma Undergoing High-Dose Therapy and Autologous Hematopoietic Cell Transplantation (HDT-AHCT)
Abstract: HDT-AHCT is a standard and potentially curative therapy for patients with high risk, chemosensitive lymphomas. Improvements in supportive care and HCT practices have [...]
Endothelial transplantation rejuvenates aged hematopoietic stem cell function
Abstract: Age-related changes in the hematopoietic compartment are primarily attributed to cell-intrinsic alterations in hematopoietic stem cells (HSCs); however, the contribution of the aged microenvironment [...]
Conversion of adult endothelium to immunocompetent hematopoietic stem cells
Abstract: Developmental pathways that orchestrate the fleeting transition of endothelial cells into hematopoietic stem cells remain undefined. Here we demonstrate a tractable approach for fully [...]
Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates
Abstract: Successful expansion of bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs) would benefit many HSPC transplantation and gene therapy/editing applications. However, current expansion [...]
Angiocrine functions of organ-specific endothelial cells
Abstract: Endothelial cells that line capillaries are not just passive conduits for delivering blood. Tissue-specific endothelium establishes specialized vascular niches that deploy sets of growth [...]
Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells
Abstract: Pluripotent stem cells (PSCs) represent an alternative hematopoietic stem cell (HSC) source for treating hematopoietic disease. The limited engraftment of human PSC–derived (hPSC-derived) multipotent [...]
Reprogramming human endothelial cells to haematopoietic cells requires vascular induction
Abstract: Generating engraftable human haematopoietic cells from autologous tissues is a potential route to new therapies for blood diseases. However, directed differentiation of pluripotent stem [...]
Endothelial signaling in kidney morphogenesis: a role for hemodynamic forces
Abstract: The local presence of endothelial cells seems necessary for proper embryonic development of several organs. However, the signals involved are unknown. The glomerulus is [...]
Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning
This work looked at the process of how the vasculature is stimulated to promote gonad development. Cool found that the interstitial cells express Vegfa, which [...]
Liver organogenesis promoted by endothelial cells prior to vascular function
Angiocrine factors from the vasculature were required to initiate proper hepatic outgrowth and morphogenesis. Science. 2001 Oct 19;294(5542):559-63. Epub 2001 Sep 27. Matsumoto K1, Yoshitomi [...]