Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning

This work looked at the process of how the vasculature is stimulated to promote gonad development. Cool found that the interstitial cells express Vegfa, which was reciprocated by the endothelial cells with PDGF-BB. Pertubation of this interaction resulted in the reduction of proliferation and improper morphology within the gonad.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):167-72. doi: 10.1073/pnas.1010299108. Epub 2010 Dec 20.

Cool J1, DeFalco TJ, Capel B.

1Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

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