Identification of a clonally expanding haematopoietic compartment in bone marrow

This work provides a detailed structure of the vascular niche within the bone marrow. Of the cells found within this vascular niche were the primitive CD150+ CD48- presumptive hematopoietic stem cells. Disruption of the endothelial cells via VEGFR2 ablation resulted in the destruction of this niche’s capacity to support the hematopoietic stem cells.

EMBO J. 2013 Jan 23;32(2):219-30. doi: 10.1038/emboj.2012.308. Epub 2012 Nov 27.

Wang L1, Benedito R, Bixel MG, Zeuschner D, Stehling M, Sävendahl L, Haigh JJ, Snippert H, Clevers H, Breier G, Kiefer F, Adams RH.

1Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, University of Münster, Münster, Germany.

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