Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization

After the removal of a single lung, the remaining lung is capable of compensatory growth in an Angiocrine factor dependent manner. Endothelial cells are capable of activating EGF to promote tissue regeneration. Notably, this feat is specific to lung endothelial cells, and not liver endothelial cells highlighting the tissue specificity of Angiocrine Factors.

Cell. 2011 Oct 28;147(3):539-53. doi: 10.1016/j.cell.2011.10.003.

Ding BS1, Nolan DJ, Guo P, Babazadeh AO, Cao Z, Rosenwaks Z, Crystal RG, Simons M, Sato TN, Worgall S, Shido K, Rabbany SY, Rafii S.

1Ansary Stem Cell Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

GO TO PUBMED>