Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells

The vasculature of the bone marrow is indispensable for the recovery of blood lineages after myeloablative stresses. Disruption of the endothelial cells’ ability to produce Angiocrine factors was tantamount to demise.

Cell Stem Cell. 2010 Mar 5;6(3):251-64. doi: 10.1016/j.stem.2010.02.001.

Butler JM1, Nolan DJ, Vertes EL, Varnum-Finney B, Kobayashi H, Hooper AT, Seandel M, Shido K, White IA, Kobayashi M, Witte L, May C, Shawber C, Kimura Y, Kitajewski J, Rosenwaks Z, Bernstein ID, Rafii S.

1Howard Hughes Medical Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA.