Development of a vascular niche platform for expansion of repopulating human cord blood stem and progenitor cells

This is the first demonstration that freshly isolated human umbilical cord blood-derived hematopoietic stem and progenitor cells expand on the VeraVec platform. The expansion gives rise to a multilineage engraftment in primary and secondary recipients. Most notably, the incidence of long term repopulating stem cells within the expanded population is higher when co-cultured with VeraVecs compared to freshly isolated and cytokine expanded conditions.

Blood. 2012 Aug 9;120(6):1344-7. doi: 10.1182/blood-2011-12-398115. Epub 2012 Jun 18.

Butler JM1, Gars EJ, James DJ, Nolan DJ, Scandura JM, Rafii S.

1Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA. jmb2009@med.cornell.edu

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