Circulating Tumor Cells from Prostate Cancer Patients Interact with E-Selectin under Physiologic Blood Flow

Gakhar and colleagues investigated the ability for prostate cancer (PCa) to bind E-selectin as a mechanism for extravasation and metastasis. VeraVec ECs (E4ORF1 HUVECs) were the cell of choice in their assays to avoid the technical restrains of working with naïve HUVECs.

PLoS One. 2013 Dec 27;8(12):e85143. doi: 10.1371/journal.pone.0085143. eCollection 2013.

Gakhar G1, Navarro VN, Jurish M, Lee GY, Tagawa ST, Akhtar NH, Seandel M, Geng Y, Liu H, Bander NH, Giannakakou P, Christos PJ, King MR, Nanus DM.

1Deparment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, New York, United States of America.

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