Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells

The features of the VeraVec technology are based in the modest activation of Akt1 without the need for any oncogenic activity or transformation. Only through this slight stimulation can endothelial cells be both serum independent can capable of being an expanding co-culture platform.

Nat Cell Biol. 2010 Nov;12(11):1046-56. doi: 10.1038/ncb2108. Epub 2010 Oct 24.

Kobayashi H1, Butler JM, O’Donnell R, Kobayashi M, Ding BS, Bonner B, Chiu VK, Nolan DJ, Shido K, Benjamin L, Rafii S.

1Howard Hughes Medical Institute, Ansary Stem Cell Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

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